Refiloe has a degree in Politics and Philosophy from the University of Cape Town, and a Post-Graduate Diploma in Marketing. During her years at UCT, she was a national executive member of SALSA (South African Liberal Students Association) in the 1990s and joined the DA in 2001.
After qualifying at university she held a range of marketing positions in various corporations including: The Foschini Group, Capespan, SAA, ABSA and SABC.
She was appointed in 2009 as the DA’s national director of the LEAD programme which increased communication with voters in traditional ANC support areas. She left this position when she became the councillor for Ward 24 in Ekurhuleni in 2011, a position she held until 2014.
In 2012, while still a councillor, she was appointed as the DA’s Gauteng provincial spokesperson. After the May 2014 elections, she was elected as a member of the Gauteng Provincial Legislature and is currently the shadow MEC for Social Development and a member of the Health Portfolio. She is also the DA Political Head for Kempton Park and Tembisa.
On the 10th of May 2015 she was elected one of the three deputy federal chairpersons for the DA.
Refiloe is a mother to three small children, and has co-authored a novel which she hopes to publish soon.